MEME -- Multiple EM for Motif Elicitation

Motif discovery tool

Overview

MEME is a tool for discovering motifs in a group of related DNA or protein sequences.

A motif is a sequence pattern that occurs repeatedly in a group of related protein or DNA sequences. MEME represents motifs as position-dependent letter-probability matrices which describe the probability of each possible letter at each position in the pattern. Individual MEME motifs do not contain gaps. Patterns with variable-length gaps are split by MEME into two or more separate motifs.

MEME takes as input a group of DNA or protein sequences (the training set) and outputs as many motifs as requested. MEME uses statistical modeling techniques to automatically choose the best width, number of occurrences, and description for each motif.

MEME sends you three e-mail messages:

• a confirmation message,
• the MEME results, and
• the MAST results of searching the training set for the motifs found by MEME using MAST.

Discover motifs using MEME.