MAST - Motif Alignment and Search Tool
MAST version 3.0 (Release date: 2000/11/27 13:23:40)
For further information on how to interpret these results or to get
a copy of the MAST software please access http://meme.sdsc.edu.
REFERENCE
If you use this program in your research, please cite:
Timothy L. Bailey and Michael Gribskov,
"Combining evidence using p-values: application to sequence homology
searches", Bioinformatics, 14(48-54), 1998.
DATABASE AND MOTIFS
DATABASE adh.s (peptide)
Last updated on Mon Nov 27 05:23:45 2000
Database contains 33 sequences, 9996 residues
MOTIFS meme.adh.zoops.sunsparcsolaris.html (peptide)
MOTIF WIDTH BEST POSSIBLE MATCH
----- ----- -------------------
1 22 YCASKFAVRMLTRSMAMEYAPH
2 25 QGKVVLITGCSSGIGKATAKHLHKE
3 13 YGPVDVLVNNAGI
PAIRWISE MOTIF CORRELATIONS:
MOTIF 1 2
----- ----- -----
2 0.32
3 0.21 0.31
No overly similar pairs (correlation > 0.60) found.
Random model letter frequencies (from non-redundant database):
A 0.073 C 0.018 D 0.052 E 0.062 F 0.040 G 0.069 H 0.022 I 0.056 K 0.058
L 0.092 M 0.023 N 0.046 P 0.051 Q 0.041 R 0.052 S 0.074 T 0.059 V 0.064
W 0.013 Y 0.033
SECTION I: HIGH-SCORING SEQUENCES
- Each of the following 33 sequences has E-value less than 10.
- The E-value of a sequence is the expected number of sequences
in a random database of the same size that would match the motifs as
well as the sequence does and is equal to the combined p-value of the
sequence times the number of sequences in the database.
- The combined p-value of a sequence measures the strength of the
match of the sequence to all the motifs and is calculated by
- finding the score of the single best match of each motif
to the sequence (best matches may overlap),
- calculating the sequence p-value of each score,
- forming the product of the p-values,
- taking the p-value of the product.
- The sequence p-value of a score is defined as the
probability of a random sequence of the same length containing
some match with as good or better a score.
- The score for the match of a position in a sequence to a motif
is computed by by summing the appropriate entry from each column of
the position-dependent scoring matrix that represents the motif.
- Sequences shorter than one or more of the motifs are skipped.
- The table is sorted by increasing E-value.
| Links | Sequence Name | Description | E-value | Length
|
|---|
|
| YRTP_BACSU
| HYPOTHETICAL 25.3 KD PROTEIN IN RTP...
| 8.9e-38
| 238
|
|
| BUDC_KLETE
| ACETOIN(DIACETYL) REDUCTASE (EC 1.1...
| 6.8e-35
| 241
|
|
| HDE_CANTR
| HYDRATASE-DEHYDROGENASE-EPIMERASE (...
| 2.6e-31
| 906
|
|
| 3BHD_COMTE
| 3-BETA-HYDROXYSTEROID DEHYDROGENASE...
| 8.1e-31
| 253
|
|
| FVT1_HUMAN
| no comment
| 3.3e-30
| 332
|
|
| YINL_LISMO
| HYPOTHETICAL 26.8 KD PROTEIN IN INL...
| 6.5e-30
| 248
|
|
| AP27_MOUSE
| ADIPOCYTE P27 PROTEIN (AP27)
| 6.8e-30
| 244
|
|
| NODG_RHIME
| NODULATION PROTEIN G (HOST-SPECIFIC...
| 1.2e-29
| 245
|
|
| DHGB_BACME
| GLUCOSE 1-DEHYDROGENASE B (EC 1.1.1...
| 1.6e-29
| 262
|
|
| BA72_EUBSP
| 7-ALPHA-HYDROXYSTEROID DEHYDROGENAS...
| 5.4e-29
| 249
|
|
| HDHA_ECOLI
| 7-ALPHA-HYDROXYSTEROID DEHYDROGENAS...
| 8.9e-29
| 255
|
|
| DHES_HUMAN
| ESTRADIOL 17 BETA-DEHYDROGENASE (EC...
| 4.2e-28
| 327
|
|
| DHCA_HUMAN
| no comment
| 5.8e-28
| 276
|
|
| BPHB_PSEPS
| BIPHENYL-CIS-DIOL DEHYDROGENASE (EC...
| 1e-27
| 275
|
|
| 2BHD_STREX
| 20-BETA-HYDROXYSTEROID DEHYDROGENAS...
| 2.2e-27
| 255
|
|
| DHII_HUMAN
| CORTICOSTEROID 11-BETA-DEHYDROGENAS...
| 4.1e-27
| 292
|
|
| FIXR_BRAJA
| FIXR PROTEIN
| 9.8e-27
| 278
|
|
| HMTR_LEIMA
| no comment
| 1.8e-26
| 287
|
|
| ENTA_ECOLI
| 2,3-DIHYDRO-2,3-DIHYDROXYBENZOATE D...
| 7.4e-26
| 248
|
|
| BDH_HUMAN
| D-BETA-HYDROXYBUTYRATE DEHYDROGENAS...
| 1.4e-25
| 343
|
|
| DHB2_HUMAN
| no comment
| 4.7e-25
| 387
|
|
| RIDH_KLEAE
| RIBITOL 2-DEHYDROGENASE (EC 1.1.1.5...
| 4.9e-25
| 249
|
|
| DHMA_FLAS1
| N-ACYLMANNOSAMINE 1-DEHYDROGENASE (...
| 1.3e-24
| 270
|
|
| GUTD_ECOLI
| SORBITOL-6-PHOSPHATE 2-DEHYDROGENAS...
| 3e-24
| 259
|
|
| DHB3_HUMAN
| no comment
| 3.8e-24
| 310
|
|
| MAS1_AGRRA
| no comment
| 5.1e-19
| 476
|
|
| ADH_DROME
| ALCOHOL DEHYDROGENASE (EC 1.1.1.1)
| 7e-19
| 255
|
|
| RFBB_NEIGO
| no comment
| 1.8e-16
| 346
|
|
| CSGA_MYXXA
| no comment
| 2.7e-16
| 166
|
|
| PCR_PEA
| no comment
| 7.9e-16
| 399
|
|
| LIGD_PSEPA
| C ALPHA-DEHYDROGENASE (EC -.-.-.-)
| 8.2e-16
| 305
|
|
| YURA_MYXXA
| no comment
| 2.6e-13
| 258
|
|
| FABI_ECOLI
| no comment
| 6.1e-07
| 262
|
SECTION II: MOTIF DIAGRAMS
- The ordering and spacing of all non-overlapping motif occurrences
are shown for each high-scoring sequence listed in Section I.
- A motif occurrence is defined as a position in the sequence whose
match to the motif has POSITION p-value less than 0.0001.
- The POSITION p-value of a match is the probability of
a single random subsequence of the length of the motif
scoring at least as well as the observed match.
- For each sequence, all motif occurrences are shown unless there
are overlaps. In that case, a motif occurrence is shown only if its
p-value is less than the product of the p-values of the other
(lower-numbered) motif occurrences that it overlaps.
- The table also shows the E-value of each sequence.
- Spacers and motif occurences are indicated by
- occurrence of motif `n' with p-value less than 0.0001.
- Sequences longer than 1000 are not shown to scale and are indicated by thicker lines.
| Links | Name | Expect | Motifs
|
|---|
|
| YRTP_BACSU
| 8.9e-38
|
|
|
| BUDC_KLETE
| 6.8e-35
|
|
|
| HDE_CANTR
| 2.6e-31
|
|
|
| 3BHD_COMTE
| 8.1e-31
|
|
|
| FVT1_HUMAN
| 3.3e-30
|
|
|
| YINL_LISMO
| 6.5e-30
|
|
|
| AP27_MOUSE
| 6.8e-30
|
|
|
| NODG_RHIME
| 1.2e-29
|
|
|
| DHGB_BACME
| 1.6e-29
|
|
|
| BA72_EUBSP
| 5.4e-29
|
|
|
| HDHA_ECOLI
| 8.9e-29
|
|
|
| DHES_HUMAN
| 4.2e-28
|
|
|
| DHCA_HUMAN
| 5.8e-28
|
|
|
| BPHB_PSEPS
| 1e-27
|
|
|
| 2BHD_STREX
| 2.2e-27
|
|
|
| DHII_HUMAN
| 4.1e-27
|
|
|
| FIXR_BRAJA
| 9.8e-27
|
|
|
| HMTR_LEIMA
| 1.8e-26
|
|
|
| ENTA_ECOLI
| 7.4e-26
|
|
|
| BDH_HUMAN
| 1.4e-25
|
|
|
| DHB2_HUMAN
| 4.7e-25
|
|
|
| RIDH_KLEAE
| 4.9e-25
|
|
|
| DHMA_FLAS1
| 1.3e-24
|
|
|
| GUTD_ECOLI
| 3e-24
|
|
|
| DHB3_HUMAN
| 3.8e-24
|
|
|
| MAS1_AGRRA
| 5.1e-19
|
|
|
| ADH_DROME
| 7e-19
|
|
|
| RFBB_NEIGO
| 1.8e-16
|
|
|
| CSGA_MYXXA
| 2.7e-16
|
|
|
| PCR_PEA
| 7.9e-16
|
|
|
| LIGD_PSEPA
| 8.2e-16
|
|
|
| YURA_MYXXA
| 2.6e-13
|
|
|
| FABI_ECOLI
| 6.1e-07
|
|
| SCALE
|
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| 1
| 25
| 50
| 75
| 100
| 125
| 150
| 175
| 200
| 225
| 250
| 275
| 300
| 325
| 350
| 375
| 400
| 425
| 450
| 475
| 500
| 525
| 550
| 575
| 600
| 625
| 650
| 675
| 700
| 725
| 750
| 775
| 800
| 825
| 850
| 875
| 900
| |
|
|---|
SECTION III: ANNOTATED SEQUENCES
- The positions and p-values of the non-overlapping motif occurrences
are shown above the actual sequence for each of the high-scoring
sequences from Section I.
- A motif occurrence is defined as a position in the sequence whose
match to the motif has POSITION p-value less than 0.0001 as
defined in Section II.
- For each sequence, the first line specifies the name of the sequence.
- The second (and possibly more) lines give a description of the
sequence.
- Following the description line(s) is a line giving the length,
combined p-value, and E-value of the sequence as defined in Section I.
- The next line reproduces the motif diagram from Section II.
- The entire sequence is printed on the following lines.
- Motif occurrences are indicated directly above their positions in the
sequence on lines showing
- the motif number of the occurrence,
- the position p-value of the occurrence,
- the best possible match to the motif, and
- columns whose match to the motif has a positive score (indicated
by a plus sign).
YRTP_BACSU
HYPOTHETICAL 25.3 KD PROTEIN IN RTP 5'REGION (ORF238)
LENGTH = 238 COMBINED P-VALUE = 2.70e-39 E-VALUE = 8.9e-38
DIAGRAM: 4-[2]-51-[3]-61-[1]-62
[2]
2.0e-20
QGKVVLITGCSSGIGKATAKHLHKE
+++ +++++++++++++++++++++
1 MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVEKVAEEVKALGVKAAFAAADVKDADQVNQAVA
[3]
1.3e-12
YGPVDVLVNNAGI
++ ++++++++++
76 QVKEQLGDIDILINNAGISKFGGFLDLSADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAA
[1]
2.0e-18
YCASKFAVRMLTRSMAMEYAPH
++++++++ +++++++++++++
151 VTSAYSASKFAVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVAQLKLDPR
BUDC_KLETE
ACETOIN(DIACETYL) REDUCTASE (EC 1.1.1.5) (ACETOIN DEHYDROGENASE)
LENGTH = 241 COMBINED P-VALUE = 2.07e-36 E-VALUE = 6.8e-35
DIAGRAM: [2]-51-[3]-62-[1]-68
[2]
1.5e-20
QGKVVLITGCSSGIGKATAKHLHKE
+++++++++++++++++++++++++
1 MQKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATATAVAAEINQAGGRAVAIKVDVSRRDQVFAAVEQARK
[3]
7.9e-11
YGPVDVLVNNAGI
+++ ++ ++++++
76 ALGGFNVIVNNAGIAPSTPIESITEEIVDRVYNINVKGVIWGMQAAVEAFKKEGHGGKIVNACSQAGHVGNPELA
[1]
3.9e-17
YCASKFAVRMLTRSMAMEYAPH
+++++++++++++++++++++
151 VYSSSKFAVRGLTQTAARDLAPLGITVNGFCPGIVKTPMWAEIDRQCRKRRANRWATARLNLPNASPLAACRSLK
HDE_CANTR
HYDRATASE-DEHYDROGENASE-EPIMERASE (HDE)
LENGTH = 906 COMBINED P-VALUE = 7.89e-33 E-VALUE = 2.6e-31
DIAGRAM: 6-[2]-57-[3]-61-[1]-136-[2]-47-[3]-61-[1]-240-[2]-153
[2]
7.4e-15
QGKVVLITGCSSGIGKATAKHLHKE
++++++++++++++++ +++++++
1 MSPVDFKDKVVIITGAGGGLGKYYSLEFAKLGAKVVVNDLGGALNGQGGNSKAADVVVDEIVKNGGVAVADYNNV
[3]
5.3e-11
YGPVDVLVNNAGI
++++ + ++++++
76 LDGDKIVETAVKNFGTVHVIINNAGILRDASMKKMTEKDYKLVIDVHLNGAFAVTKAAWPYFQKQKYGRIVNTSS
[1]
9.2e-11
YCASKFAVRMLTRSMAMEYAPH
+ +++ ++ ++ ++++++ +++
151 PAGLYGNFGQANYASAKSALLGFAETLAKEGAKYNIKANAIAPLARSRMTESILPPPMLEKLGPEKVAPLVLYLS
[2]
9.6e-19
QGKVVLITGCSSGIGKATAKHLHKE
+++++++++++ +++++++++++++
301 TNEARKLPANDASGAPTVSLKDKVVLITGAGAGLGKEYAKWFAKYGAKVVVNDFKDATKTVDEIKAAGGEAWPDQ
[3]
1.6e-14
YGPVDVLVNNAGI
+++++++++++++
376 HDVAKDSEAIIKNVIDKYGTIDILVNNAGILRDRSFAKMSKQEWDSVQQVHLIGTFNLSRLAWPYFVEKQFGRII
[1]
2.2e-13
YCASKFAVRMLTRSMAMEYAPH
++++++++ +++++++ + ++
451 NITSTSGIYGNFGQANYSSSKAGILGLSKTMAIEGAKNNIKVNIVAPHAETAMTLTIFREQDKNLYHADQVAPLL
[2]
6.8e-05
QGKVVLITGCSSGIGKATAKHL
++ ++++ +++ + +
676 FNSGKSQNSFAKLLRNFNPMLLLHGEHYLKVHSWPPPTEGEIKTTFEPIATTPKGTNVVIVHGSKSVDNKSGELI
HKE
+++
751 YSNEATYFIRNCQADNKVYADRPAFATNQFLAPKRAPDYQVDVPVSEDLAALYRLSGDRNPLHIDPNFAKGAKFP
3BHD_COMTE
3-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.51)
LENGTH = 253 COMBINED P-VALUE = 2.44e-32 E-VALUE = 8.1e-31
DIAGRAM: 4_[2]_48_[3]_60_[1]_81
[2]
5.5e-17
QGKVVLITGCSSGIGKATAKHLHKE
+++++++++++++++++ ++ ++ +
1 TNRLQGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELGERSMFVRHDVSSEADWTLVMAAVQ
[3]
1.9e-12
YGPVDVLVNNAGI
+++++++++++++
76 RRLGTLNVLVNNAGILLPGDMETGRLEDFSRLLKINTESVFIGCQQGIAAMKETGGSIINMASVSSWLPIEQYAG
[1]
5.3e-15
YCASKFAVRMLTRSMAMEYAPH
+++++++++++++++++ ++++
151 YSASKAAVSALTRAAALSCRKQGYAIRVNSIHPDGIYTPMMQASLPKGVSKEMVLHDPKLNRAGRAYMPERIAQL
FVT1_HUMAN
no comment
LENGTH = 332 COMBINED P-VALUE = 1.01e-31 E-VALUE = 3.3e-30
DIAGRAM: 30-[2]-56-[3]-61-[1]-125
[2]
6.9e-16
QGKVVLITGCSSGIGKATAKHLHKE
+ ++++++++++++++++++++++
1 MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKE
[3]
1.6e-11
YGPVDVLVNNAGI
+++++++++ +++
76 IEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSV
[1]
9.2e-17
YCASKFAVRMLTRSMAMEYAPH
+++++++++++ ++++++++++
151 YPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFA
YINL_LISMO
HYPOTHETICAL 26.8 KD PROTEIN IN INLA 5'REGION (ORFA)
LENGTH = 248 COMBINED P-VALUE = 1.97e-31 E-VALUE = 6.5e-30
DIAGRAM: 3-[2]-51-[3]-61-[1]-73
[2]
7.5e-20
QGKVVLITGCSSGIGKATAKHLHKE
++++++++++++++++++++ ++++
1 MTIKNKVIIITGASSGIGKATALLLAEKGAKLVLAARRVEKLEKIVQIIKANSGEAIFAKTDVTKREDNKKLVEL
[3]
2.2e-09
YGPVDVLVNNAGI
++++++ ++++
76 AIERYGKVDAIFLNAGIMPNSPLSALKEDEWEQMIDINIKGVLNGIAAVLPSFIAQKSGHIIATSSVAGLKAYPG
[1]
3.1e-14
YCASKFAVRMLTRSMAMEYAPH
+++++++++ +++ ++++ +++
151 GAVYGATKWAVRDLMEVLRMESAQEGTNIRTATIYPAAINTELLETITDKETEQGMTSLYKQYGITPDRIASIVA
AP27_MOUSE
ADIPOCYTE P27 PROTEIN (AP27)
LENGTH = 244 COMBINED P-VALUE = 2.06e-31 E-VALUE = 6.8e-30
DIAGRAM: 5-[2]-43-[3]-62-[1]-74
[2] [3
7.6e-16 2.
QGKVVLITGCSSGIGKATAKHLHKE YG
++ ++++++++++++ ++++++++ +
1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDATEKALGGIG
] [1
2e-10 3.
PVDVLVNNAGI YC
+++++++++ ++
76 PVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYS
]
4e-17
ASKFAVRMLTRSMAMEYAPH
++++++++++++++++++++
151 STKGAMTMLTKAMAMELGPHKIRVNSVNPTVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSD
NODG_RHIME
NODULATION PROTEIN G (HOST-SPECIFICITY OF NODULATION PROTEIN C)
LENGTH = 245 COMBINED P-VALUE = 3.54e-31 E-VALUE = 1.2e-29
DIAGRAM: 4-[2]-48-[3]-61-[1]-72
[2]
1.6e-14
QGKVVLITGCSSGIGKATAKHLHKE
++ ++++++++ ++ ++++ ++++
1 MFELTGRKALVTGASGAIGGAIARVLHAQGAIVGLHGTQIEKLETLATELGDRVKLFPANLANRDEVKALGQRAE
[3]
1.3e-12
YGPVDVLVNNAGI
+ +++++++++++
76 ADLEGVDILVNNAGITKDGLFLHMADPDWDIVLEVNLTAMFRLTREITQQMIRRRNGRIINVTSVAGAIGNPGQT
[1]
4.6e-16
YCASKFAVRMLTRSMAMEYAPH
+++++++++++++++++++++
151 NYCASKAGMIGFSKSLAQEIATRNITVNCVAPGFIESAMTDKLNHKQKEKIMVAIPIHRMGTGTEVASAVAYLAS
DHGB_BACME
GLUCOSE 1-DEHYDROGENASE B (EC 1.1.1.47)
LENGTH = 262 COMBINED P-VALUE = 4.93e-31 E-VALUE = 1.6e-29
DIAGRAM: 5-[2]-53-[3]-63-[1]-81
[2]
1.3e-16
QGKVVLITGCSSGIGKATAKHLHKE
+++++++++++ +++++++++++++
1 MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEEIKKVGGEAIAVKGDVTVESDVIN
[3]
3.4e-12
YGPVDVLVNNAGI
+++++++++++++
76 LVQSAIKEFGKLDVMINNAGMENPVSSHEMSLSDWNKVIDTNLTGAFLGSREAIKYFVENDIKGTVINMSSVHEW
[1]
2.5e-14
YCASKFAVRMLTRSMAMEYAPH
+ +++++++ ++++++++++++
151 KIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPEQRADVESMIPMGYIGEPEE
BA72_EUBSP
7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (BILE ACID 7-DEHYDROXYLASE) (BILE ACID-INDUCIBLE PROTEIN)
LENGTH = 249 COMBINED P-VALUE = 1.63e-30 E-VALUE = 5.4e-29
DIAGRAM: 4-[2]-53-[3]-61-[1]-71
[2]
3.2e-16
QGKVVLITGCSSGIGKATAKHLHKE
++++ +++++ ++++++ ++ ++ +
1 MNLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSRDAVMAA
[3]
1.2e-13
YGPVDVLVNNAGI
+++++++++++++
76 VGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIMDINVTGVFNGAWCAYQCMKDAKKGVIINTASVTGIFG
[1]
1.2e-12
YCASKFAVRMLTRSMAMEYAPH
+ +++++++++++ + +++ ++
151 SLSGVGYPASKASVIGLTHGLGREIIRKNIRVVGVAPGVVNTDMTNGNPPEIMEGYLKALPMKRMLEPEEIANVY
HDHA_ECOLI
7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (HSDH)
LENGTH = 255 COMBINED P-VALUE = 2.69e-30 E-VALUE = 8.9e-29
DIAGRAM: 9-[2]-51-[3]-60-[1]-75
[2]
3.6e-17
QGKVVLITGCSSGIGKATAKHLHKE
+++++++++++ +++++++++++++
1 MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQEL
[3]
6.6e-12
YGPVDVLVNNAGI
++++++++++++
76 SALADFAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAE
[1]
2.9e-13
YCASKFAVRMLTRSMAMEYAPH
+ +++++ +++++ ++++++++
151 NKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIA
DHES_HUMAN
ESTRADIOL 17 BETA-DEHYDROGENASE (EC 1.1.1.62) (20 ALPHA-HYDROXYSTEROID DEHYDROGENASE) (E2DH) (17-BETA-HSD) (PLACENTAL 17-BETA-HYDROXYSTEROID DEHYDROGENASE)
LENGTH = 327 COMBINED P-VALUE = 1.27e-29 E-VALUE = 4.2e-28
DIAGRAM: [2]-55-[3]-61-[1]-151
[2]
3.3e-15
QGKVVLITGCSSGIGKATAKHLHKE
++++++++++++++++ +++++
1 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAA
[3]
3.2e-11
YGPVDVLVNNAGI
++++++++ +++
76 RERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLP
[1]
1.4e-15
YCASKFAVRMLTRSMAMEYAPH
+++++++++++++++++ + +
151 FNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQV
DHCA_HUMAN
no comment
LENGTH = 276 COMBINED P-VALUE = 1.75e-29 E-VALUE = 5.8e-28
DIAGRAM: 2-[2]-52-[3]-100-[1]-62
[2]
1.1e-15
QGKVVLITGCSSGIGKATAKHLHKE
++++++++++++++++++++++
1 SSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDF
[3]
2.9e-15
YGPVDVLVNNAGI
+++++++++++++
76 LRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCS
[1]
1.2e-10
YCASKFAVRMLTRSMAMEYAPH
++ ++ +++ +++ +++ ++++
151 PELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNAC
BPHB_PSEPS
BIPHENYL-CIS-DIOL DEHYDROGENASE (EC 1.3.1.-)
LENGTH = 275 COMBINED P-VALUE = 3.08e-29 E-VALUE = 1e-27
DIAGRAM: 3-[2]-47-[3]-64-[1]-101
[2]
8.3e-16
QGKVVLITGCSSGIGKATAKHLHKE
++ +++++++++++++++ +++++
1 MKLKGEAVLITGGASGLGRALVDRFVAEAKVAVLDKSAERLAELETDLGDNVLGIVGDVRSLEDQKQAASRCVAR
[3]
1.5e-10
YGPVDVLVNNAGI
+++++ ++ ++++
76 FGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHINVKGYIHAVKALPALVASRGNVIFTISNAGFYPNGGG
[1]
5.3e-15
YCASKFAVRMLTRSMAMEYAPH
++++++++ +++++++++++++
151 PLYTAAKQAIVGLVRELAFELAPYVRVNGVGPGGMNSDMRGPSSLGMGSKAISTVPLADMLKSVLPIGRMPEVEE
2BHD_STREX
20-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.53)
LENGTH = 255 COMBINED P-VALUE = 6.56e-29 E-VALUE = 2.2e-27
DIAGRAM: 4_[2]_48_[3]_61_[1]_82
[2]
4.8e-14
QGKVVLITGCSSGIGKATAKHLHKE
+++ +++++++++++ + +++ +++
1 MNDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAR
[3]
4.4e-13
YGPVDVLVNNAGI
++ ++ +++++++
76 EEFGSVDGLVNNAGISTGMFLETESVERFRKVVDINLTGVFIGMKTVIPAMKDAGGGSIVNISSAAGLMGLALTS
[1]
8.8e-14
YCASKFAVRMLTRSMAMEYAPH
+++++++++++++ +++++++
151 SYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGNEPGEIAGAVVKLL
DHII_HUMAN
CORTICOSTEROID 11-BETA-DEHYDROGENASE (EC 1.1.1.146) (11-DH) (11-BETA- HYDROXYSTEROID DEHYDROGENASE) (11-BETA-HSD)
LENGTH = 292 COMBINED P-VALUE = 1.23e-28 E-VALUE = 4.1e-27
DIAGRAM: 32-[2]-52-[3]-60-[1]-88
[2]
7.5e-20
QGKVVLITGCSSGIGKATAKHLHKE
+++ +++++++++++++++++++++
1 MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVV
[3]
2.8e-07
YGPVDVLVNNAGI
++++++++ ++
76 SHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVL
[1]
1.1e-13
YCASKFAVRMLTRSMAMEYAPH
+++++++++++ ++ +++++ +
151 TVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMK
FIXR_BRAJA
FIXR PROTEIN
LENGTH = 278 COMBINED P-VALUE = 2.98e-28 E-VALUE = 9.8e-27
DIAGRAM: 34-[2]-49-[3]-67-[1]-68
[2]
1.7e-16
QGKVVLITGCSSGIGKATAKHLHKE
+ ++++ +++++++++++++ + ++
1 MGLDLPNDNLIRGPLPEAHLDRLVDAVNARVDRGEPKVMLLTGASRGIGHATAKLFSEAGWRIISCARQPFDGER
[3]
3.6e-09
YGPVDVLVNNAGI
++ ++++++++
76 CPWEAGNDDHFQVDLGDHRMLPRAITEVKKRLAGAPLHALVNNAGVSPKTPTGDRMTSLTTSTDTWMRVFHLNLV
[1]
1.0e-14
YCASKFAVRMLTRSMAMEYAPH
+ +++++ +++++++++++++
151 APILLAQGLFDELRAASGSIVNVTSIAGSRVHPFAGSAYATSKAALASLTRELAHDYAPHGIRVNAIAPGEIRTD
HMTR_LEIMA
no comment
LENGTH = 287 COMBINED P-VALUE = 5.59e-28 E-VALUE = 1.8e-26
DIAGRAM: 4-[2]-70-[3]-80-[1]-73
[2]
1.6e-14
QGKVVLITGCSSGIGKATAKHLHKE
+ ++++++++++ +++++++ ++++
1 MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVS
[3]
6.7e-11
YGPVDVLVNNAGI
+++++++++++
76 GADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIA
[1]
1.0e-14
YCASKFAVRMLTRSMAMEYAPH
+++++++++++++++++++++
151 PYFLIKAFAHRSRHPSQASRTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGL
ENTA_ECOLI
2,3-DIHYDRO-2,3-DIHYDROXYBENZOATE DEHYDROGENASE (EC 1.3.1.28)
LENGTH = 248 COMBINED P-VALUE = 2.25e-27 E-VALUE = 7.4e-26
DIAGRAM: 3-[2]-41-[3]-61-[1]-83
[2] [3]
4.2e-18 1.0e-0
QGKVVLITGCSSGIGKATAKHLHKE YGPVDV
+++++++++++++++++++++++++ + ++++
1 MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDA
[1]
9 1.8e-11
LVNNAGI YCASKFA
+++ +++ +++++++
76 LVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAA
VRMLTRSMAMEYAPH
++++ + ++++ +
151 LKSLALSVGLELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFL
BDH_HUMAN
D-BETA-HYDROXYBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.30) (BDH) (3-HYDROXYBUTYRATE DEHYDROGENASE) (FRAGMENT)
LENGTH = 343 COMBINED P-VALUE = 4.19e-27 E-VALUE = 1.4e-25
DIAGRAM: 53-[2]-56-[3]-60-[1]-114
[2]
3.5e-16
QGKVVLITGCSSGIGKATAKHL
++ +++++++++ ++++++++
1 GLRPPPPGRFSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHL
[3]
2.6e-10
HKE YGPVDVLVNNAGI
+++ + +++ +++++++
76 HSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVFRSEEVEKVVGDCPFEPEGPEKGMWGLVNNAGISTF
[1]
5.6e-13
YCASKFAVRMLTRSMAME
++ +++++++++ +++++
151 GEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYE
YAPH
+++
226 MYPLGVKVSVVEPGNFIAATSLYNPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
DHB2_HUMAN
no comment
LENGTH = 387 COMBINED P-VALUE = 1.41e-26 E-VALUE = 4.7e-25
DIAGRAM: 80-[2]-52-[3]-61-[1]-134
[2]
9.2e-16
QGKVVLITGCSSGIGKATAKHLHKE
+++ ++++++++++++++++++ +
76 ELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYS
[3]
4.5e-08
YGPVDVLVNNAGI
++++ ++++++
151 KVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAP
[1]
2.9e-15
YCASKFAVRMLTRSMAMEYAPH
+++++++++++++ ++++++++
226 MERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
RIDH_KLEAE
RIBITOL 2-DEHYDROGENASE (EC 1.1.1.56) (RDH)
LENGTH = 249 COMBINED P-VALUE = 1.48e-26 E-VALUE = 4.9e-25
DIAGRAM: 12-[2]-48-[3]-61-[1]-68
[2]
1.4e-16
QGKVVLITGCSSGIGKATAKHLHKE
+++++ +++++++++++++++++ +
1 MKHSVSSMNTSLSGKVAAITGAASGIGLECARTLLGAGAKVVLIDREGEKLNKLVAELGENAFALQVDLMQADQV
[3]
5.1e-08
YGPVDVLVNNAGI
++++++ +++
76 DNLLQGILQLTGRLDIFHANAGAYIGGPVAEGDPDVWDRVLHLNINAAFRCVRSVLPHLIAQKSGDIIFTAVIAG
[1]
7.2e-14
YCASKFAVRMLTRSMAMEYAPH
++++++++++++++ +++++++
151 VVPVIWEPVYTASKFAVQAFVHTTRRQVAQYGVRVGAVLPGPVVTALLDDWPKAKMDEALANGSLMQPIEVAESV
DHMA_FLAS1
N-ACYLMANNOSAMINE 1-DEHYDROGENASE (EC 1.1.1.233) (NAM-DH)
LENGTH = 270 COMBINED P-VALUE = 4.04e-26 E-VALUE = 1.3e-24
DIAGRAM: 12-[2]-46-[3]-68-[1]-8-[3]-63
[2]
1.2e-15
QGKVVLITGCSSGIGKATAKHLHKE
++ +++++++++++++++++++++
1 TTAGVSRRPGRLAGKAAIVTGAAGGIGRATVEAYLREGASVVAMDLAPRLAATRYEEPGAIPIACDLADRAAIDA
[3]
5.0e-06
YGPVDVLVNNAGI
++++++++
76 AMADAVARLGGLDILVAGGALKGGTGNFLDLSDADWDRYVDVNMTGTFLTCRAGARMAVAAGAGKDGRSARIITI
[1] [3]
4.8e-14 2.0e-08
YCASKFAVRMLTRSMAMEYAPH YGPVDVLVNNAGI
+ ++++++ +++++++++++++ +++++ ++ ++
151 GSVNSFMAEPEAAAYVAAKGGVAMLTRAMAVDLARHGILVNMIAPGPVDVTGNNTGYSEPRLAEQVLDEVALGRP
GUTD_ECOLI
SORBITOL-6-PHOSPHATE 2-DEHYDROGENASE (EC 1.1.1.140) (GLUCITOL-6- PHOSPHATE DEHYDROGENASE) (KETOSEPHOSPHATE REDUCTASE)
LENGTH = 259 COMBINED P-VALUE = 9.01e-26 E-VALUE = 3e-24
DIAGRAM: [2]-53-[3]-62-[1]-84
[2]
3.5e-12
QGKVVLITGCSSGIGKATAKHLHKE
+++++++ ++++ ++ +++ ++++
1 MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGADATSEQSCLALSRGV
[3]
4.1e-10
YGPVDVLVNNAGI
++++++++ +++
76 DEIFGRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKH
[1]
2.1e-15
YCASKFAVRMLTRSMAMEYAPH
+++++++ +++++++++++++
151 NSGYSAAKFGGVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGC
DHB3_HUMAN
no comment
LENGTH = 310 COMBINED P-VALUE = 1.14e-25 E-VALUE = 3.8e-24
DIAGRAM: 46-[2]-50-[3]-63-[1]-91
[2]
1.7e-16
QGKVVLITGCSSGIGKATAKHLHKE
+++++++++++ +++++++ +++++
1 MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYYKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNV
[3]
3.2e-07
YGPVDVLVNNAGI
+ +++++ ++
76 VLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEI
[1]
3.9e-14
YCASKFAVRMLTRSMAMEYAPH
++++++++++++++++ +++ +
151 QSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV
MAS1_AGRRA
no comment
LENGTH = 476 COMBINED P-VALUE = 1.55e-20 E-VALUE = 5.1e-19
DIAGRAM: 243-[2]-48-[3]-62-[1]-63
[2]
1.3e-14
QGKVVLITGCSSGIGKATAKHLHKE
+++++++ +++++++++++++++++
226 GRVLHFRRGFSHWTVEIHQSPVILVSGSNRGVGKAIAEDLIAHGYRLSLGARKVKDLEVAFGPQDEWLHYARFDA
[3]
1.1e-12
YGPVDVLVNNAGI
+++++ +++++++
301 EDHGTMAAWVTAAVEKFGRIDGLVNNAGYGEPVNLDKHVDYQRFHLQWYINCVAPLRMTELCLPHLYETGSGRIV
[1]
8.3e-06
YCASKFAVRMLTRSMAMEYAPH
+ +++ ++ +++++ ++
376 NINSMSGQRVLNPLVGYNMTKHALGGLTKTTQHVGWDRRCAAIDICLGFVATDMSAWTDLIASKDMIQPEDIAKL
ADH_DROME
ALCOHOL DEHYDROGENASE (EC 1.1.1.1)
LENGTH = 255 COMBINED P-VALUE = 2.12e-20 E-VALUE = 7e-19
DIAGRAM: 4-[2]-53-[3]-56-[1]-82
[2]
1.1e-11
QGKVVLITGCSSGIGKATAKHLHKE
++++++ + +++++ ++++++++
1 SFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKL
[3]
1.1e-09
YGPVDVLVNNAGI
+ +++++++ +++
76 LKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVP
[1]
9.2e-11
YCASKFAVRMLTRSMAMEYAPH
++ +++++ ++++++++ +
151 VYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKA
RFBB_NEIGO
no comment
LENGTH = 346 COMBINED P-VALUE = 5.33e-18 E-VALUE = 1.8e-16
DIAGRAM: 4-[2]-135-[1]-160
[2]
1.7e-13
QGKVVLITGCSSGIGKATAKHLHKE
+++++++++++ ++ + +++ +++
1 MQTEGKKNILVTGGAGFIGSAVVRHIIQNTRDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICDRAELDRVF
[1]
6.2e-13
YCASKFAVRMLTRSMAMEYAPH
+++++++ +++++++++ ++
151 DLFTETTPYAPSSPYSASKAAADHLVRAWQRTYRLPSIVSNCSNNYGPRQFPEKLIPLMILNALSGKPLPVYGDG
CSGA_MYXXA
no comment
LENGTH = 166 COMBINED P-VALUE = 8.26e-18 E-VALUE = 2.7e-16
DIAGRAM: 9-[3]-65-[1]-57
[3]
8.9e-13
YGPVDVLVNNAGI
+++++++++++++
1 MRAFATNVCTGPVDVLINNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLPGLRQGALRRVAHVTSRMG
[1]
1.8e-12
YCASKFAVRMLTRSMAMEYAPH
+ ++++++ + ++++ +++++
76 SLAANTDGGAYAYRMSKAALNMAVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNP
PCR_PEA
no comment
LENGTH = 399 COMBINED P-VALUE = 2.40e-17 E-VALUE = 7.9e-16
DIAGRAM: 84-[2]-52-[3]-225
[2]
7.6e-16
QGKVVLITGCSSGIGKATAKHLHKE
+ ++++++++++++++++++++++
76 SSSEGKKTLRKGNVVITGASSGLGLATAKALAESGKWHVIMACRDYLKAARAAKSAGLAKENYTIMHLDLASLDS
[3]
6.4e-10
YGPVDVLVNNAGI
+ +++++++++ +
151 VRQFVDNFRRSEMPLDVLINNAAVYFPTAKEPSFTADGFEISVGTNHLGHFLLSRLLLEDLKKSDYPSKRLIIVG
LIGD_PSEPA
C ALPHA-DEHYDROGENASE (EC -.-.-.-)
LENGTH = 305 COMBINED P-VALUE = 2.48e-17 E-VALUE = 8.2e-16
DIAGRAM: 4-[2]-127-[1]-127
[2]
9.8e-14
QGKVVLITGCSSGIGKATAKHLHKE
+++++ +++++++ ++ +++ + ++
1 MKDFQDQVAFITGGASGAGFGQAKVFGQAGAKIVVADVRAEAVEKAVAELEGLGITAHGIVLDIMDREAYARAAD
[1]
4.4e-12
YCASKFAVRMLTRSMAMEYAPH
+++++++ +++++ +++ + ++
151 SALAGPYSAAKAASINLMEGYRQGLEKYGIGVSVCTPANIKSNIAEASRLRPAKYGTSGYVENEESIASLHSIHQ
YURA_MYXXA
no comment
LENGTH = 258 COMBINED P-VALUE = 7.98e-15 E-VALUE = 2.6e-13
DIAGRAM: 86-[3]-60-[1]-77
[3]
2.0e-08
YGPVDVLVNNAGI
+++++ + ++++
76 TLERIRALDAEAGGLDLVVANAGVGGTTNAKRLPWERVRGIIDTNVTGAAATLSAVLPQMVERKRGHLVGVSSLA
[1]
2.8e-14
YCASKFAVRMLTRSMAMEYAPH
+++++++++ ++++++++++ +
151 GFRGLPATRYSASKAFLSTFMESLRVDLRGTGVRVTCIYPGFVKSELTATNNFPMPFLMETHDAVELMGKGIVRG
FABI_ECOLI
no comment
LENGTH = 262 COMBINED P-VALUE = 1.86e-08 E-VALUE = 6.1e-07
DIAGRAM: 4-[2]-129-[1]-82
[2]
2.4e-06
QGKVVLITGCSSGIGKATAKHLHKE
+++ +++++ ++ + ++ ++ + +
1 MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMF
[1]
7.7e-09
YCASKFAVRMLTRSMAMEYAPH
++ +++++++ +++++ ++++
151 RAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDV
Debugging Information
CPU: nbcr1
Time 0.220148 secs.
mast meme.adh.zoops.sunsparcsolaris.html -stdout
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